These airlines currently offer services to/from Owen Roberts International Airport, Grand Cayman. Some operate on a seasonal basis, discontinuing service in the slower summer months.
Note: This schedule is subject to change. Kindly contact respective airlines if you have any queries.
| Airline | Contact Number |
| Cayman Airways Ltd | 1-345-949-2311 or 1-800-422-9626 |
| American Airlines | 1-345-949-8156 or 1-345-945-7943 or 1-800-433-7300 |
| US Airways | 1-800-428-4322 |
| United Airlines | 1-800-525-0280 / 1-800-864-8331 |
| Delta Air Lines | 1-345-949-8700 or 1-800-221-1212 |
| Air Canada | 1-800-247-2262 |
| British Airways | 1-800-247-9297 |
| WestJet | 1-345-949-2311 |
| JetBlue Airways | 1-345-747-8402 |
